Oxidative damage to mitochondria is commonly hypothesized to play a causal role in senescence. My graduate research concerned the measurement of oxidative DNA damage, and mechanisms of its repair, in mitochondrial DNA. I published nine peer-reviewed articles in that area. After graduation, my focus shifted to a different question in the field of biogerontology. Caloric intake modulates the rate of aging in many species. As a post-doc and in my initial position as an assistant professor, I worked to develop new models for elucidating the underlying mechanism by which this modulation occurs. I published several peer-reviewed articles in this area, including a May 2003 study commented upon by major news services (CNN, CBS, etc.) which found that for C57Bl/6 mice, intermittent fasting without change in net caloric intake mimics many of the effects seen when daily caloric intake is altered. Currently, given that my present position does not include laboratory facilities, my contributions have shifted toward the intellectual (via collaborations and the publication of reviews and hypotheses papers).